Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ala-MPSD TFA | 136561-67-6 | 98.02% | 3016.76 (free base) | 1 MG
Ala-MPSD TFA is a control peptide for MPSD. In this peptide, the four serine residues of MPSD are substituted by alanines. This product is intended for research use only.
- Control peptide for MPSD
- Four serine residues substituted by alanines
- For research use only
Medchemexpress LLC SAIRGA (TFA) | 99.6% | 573.64 | 1 MG
SAIRGA (TFA) is a chemical derived from the phages phi3T, capable of recognizing phAimR in the bacterial cytosol to induce lysogeny. This product is suitable for use as a laboratory chemical in the manufacture of various substances.
- Solid appearance
- Has a purity of 99.6%
- Features a molecular weight of 573.64
- Stable under recommended storage conditions
- Suitable for research applications only
- Store at -80°C for up to 2 years or -20°C for up to 1 year (powder, sealed storage, away from moisture and light)